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Research achievement

Government Project Status

Research project Development project name Participation
Development of technology for mass production of thymidine using microorganisms Technology innovation development business Sole host
Development of skin trouble-care cosmetic materials and products containing hyaluronic acid derivatives Combined Technology Development Project Co-participation
Development of manufacturing process of Lactulose by enzymatic and chemical reactions. Industrial Technology Innovation Business Participation
Development of QbD (Quality by Design) program specialized for pharmaceutical process validation for advanced pharmaceutical quality Combined Technology Development Project Subject (joint)
Development of manufacturing process of functional sweeteners by immobilized microbial and enzymatic reactor and its industrialization Next Generation Bio Green 21 Project _ Red Green Growth Project Sole host
Commercial production technology of Coenzyme Q10 using microorganisms Industry-academy-research cooperation technology development business Participation
Development of immunostimulatory feed additive and vaccine adjuvants for animal from Mulberry Industrial Technology Innovation Business Subjectivity

Patent Status

  Registration
Designation Registration Number Registration Date Legal Status
Composition comprising the extract of Mori Fructus for immune activity 10-0839096 2008.06.11 Registration
A new compound and Composition comprising compounds isolated from the fruit extract of Morus alba L for immuno-stimulating activity 10-1460417 2014.11.04 Registration
Fermentation process for preparing thymidine by the recombinant E. coli 10-1653245 2016.08.26 Registration
Improved production of isomaltulose by a newly isolated mutant of Serratia sp. M1 10-1675096 2016.11.04 Registration
A composition comprising the extract of Morus alba L. for treating or preventing cancer disease 10-1762224 2017.07.21 Registration
Lactulose production using immobilized cells 10-1762222 2017.07.21 Registration
Rare sugar production and purification using immobilized cell reactor 10-1762227 2017.07.21 Registration
Hair loss management system 10-1826817 2018.02.01 Registration
Feed additives for immune enhancement coated with white mulberry fruit extract 10-1907135 2018.10.04 Registration
Expression and purification method of soluble protein of CRM197 10-1908590 2018.10.10 Registration
Recovery and Purification Method of Bioactive CRM197 Proteins from Inclusion Bodies Including CRM197 10-2078714 2020.02.12 Registration
  Application
Designation Application Number Application Date Legal Status
Feed additive for immunity enhancement using white mulberry fruit extract 10-2017-0183286 2017.12.29 Application
Expression and purification method of soluble protein of CRM197 PCT/KR2018/0012936 2018.01.30 Application
Recovery and Purification Method of Bioactive CRM197 Proteins from Inclusion Bodies Including CRM197 PCT/KR2018/010541 2018.09.10 Application
Veterinary composition for relieving stress of vaccinated animals 10-2018-0172660 2018.12.28 Application

Published paper

Lee, H. C., et al. (2009). "Fermentative production of thymidine by a metabolically engineered Escherichia coli strain." Appl Environ Microbiol 75(8): 2423-2432.
Lee, H. C., et al. (2009). "Thymidine production by overexpressing NAD+ kinase in an Escherichia coli recombinant strain." Biotechnol Lett 31(12): 1929-1936.
Lee, H. C., et al. (2010). "High NADPH/NADP+ ratio improves thymidine production by a metabolically engineered Escherichia coli strain." J Biotechnol 149(1-2): 24-32.
Lee, H. C., et al. (2014). "An engineered genetic selection for ternary protein complexes inspired by a natural three-component hitchhiker mechanism." Sci Rep 4: 7570.
Kim, J. S., et al. (2015). "Development of a Novel Plasmid-Free Thymidine Producer by Reprogramming Nucleotide Metabolic Pathways." Appl Environ Microbiol 81(22): 7708-7719.
Kim, J. S., et al. (2015). "Deoxycytidine production by a metabolically engineered Escherichia coli strain." Microb Cell Fact 14: 98.
Kim, J. S., et al. (2015). "Transcriptional profiling of thymidine-producing strain recombineered from Escherichia coli BL21." Genom Data 6: 63-64.
Kim, Y., et al. (2015). "Improved production of isomaltulose by a newly isolated mutant of Serratia sp. cells immobilized in calcium alginate." Can J Microbiol 61(3): 193-199.
Park, A. R., et al. (2016). “Lactulose Production Using Immobilized Cells Including Thermostable Cellobiose 2-epimerase.” Microbio. Biotechnol. Lett 44(4):504-511.
Park, A. R., et al. (2017). “Rational modification of substrate binding site by structure‑based engineering of a cellobiose 2‑epimerase in Caldicellulosiruptor saccharolyticus.” Microb Cell Fact 16:224.
Chang, B. Y., et al. (2018). “Activation of macrophage mediated host defense against Salmonella typhimuriumby Morus alba L.” Food Nutr Res 62.
Park, A. R., et al. (2018). “Efficient recovery of recombinant CRM197 expressed as inclusion bodies in E. coli.” PLoS ONE 13(7): e0201060.